The South Korean company Genexine started testing the safety of a DNA-based vaccine early in the pandemic, but a series of disappointments soon put them behind other developers. In early 2020, they began work on a Covid-19 vaccine, called CVnCoV. Over the following few weeks, the F.D.A. The head of Baqiyatallah University of Medical Sciences said in December that 5 million doses of the vaccine have been produced. The company now plans to use its vaccine platform for future pandemics. In 2020, researchers at the Icahn School of Medicine at Mount Sinai in New York developed a Covid-19 vaccine based on a virus called Newcastle Disease Virus, or NDV for short. The U.S. COVID vaccine rollout has seen over 90 million people receive at least one dose, according to Centers for Disease Control and Prevention data as of March 7. But the trial record shows that it has since been terminated, citing unsatisfactory antibody levels. Vaccinename: Comirnaty (also known as tozinameran or BNT162b2) In January 2021, Sanofi decided to help Pfizer and BioNTech make 100 million doses of their vaccine, and they reached a similar agreement with Johnson & Johnson in February.Meanwhile, Sanofi developed a stronger formulation of Vidprevtyn. Based on the level of antibodies produced by people vaccinated with Corbevax, the company estimated its efficacy to be over 90 percent against the original version of the variant. Our time frame ran from the earliest possible dates, "before 1990," to ensure every COVID vaccine was included. Stopped use in: Brazil suspended import. Check the latest statistics on Covid-19 vaccinations for countries around the world. Updated Aug. 31, 2022, PHASE 2 Updated June 13, 2022, PHASE 3 On Oct. 29, 2021, the company announced it had won approval from the South African government to start a Phase 1 trial. Overall, CVnCoV had an efficacy of just 48 percent against Covid-19. On Jan. 3, 2021 the Indian government gave Zydus Lifesciences permission to advance to a Phase 3 trial with 30,000 volunteers.The company announced on July 1 that the vaccine had an efficacy of 66.6% and that none of the vaccinated volunteers in the trial developed severe disease or died, making ZyCoV-D the first DNA-based vaccine shown to work against Covid-19. limited the use of the Johnson & Johnson vaccine, only 16.9 million people in the United States had received it. Europe Cancelling the vaccine meant the collapse of a $1 billion deal with the Australian government for 51 million doses.The vaccine studies offered great promise at first. Vaccinename: CV0501 27 due to unprecedented demand during the holiday season, nbc chicago reported. However, these trials have yet to move forward.More disappointment came in February 2022, when the company reported that the vaccine was proving less potent against the Omicron variant. In July 2020, HDT Bio teamed up with Gennova Biopharmaceuticals to launch clinical trials in India. EMERGENCY USE IN OTHER COUNTRIES In March 2021, Moderna began a Phase 1 trial of a new mRNA vaccine made specifically for the Beta variant, which yielded positive results in humans and mice.However, the first Moderna boosters to go into use were simply a third dose of the original vaccine. Emergency use in: Iran. On March 16, 2021, Irans Ministry of Defence announced the launch of a vaccine made of inactivated coronaviruses. Based on promising results in these studies, Johnson & Johnson launched a Phase 3 trial in September using just one dose rather than two. VIDO registered a Phase 1 trial for COVAC-2 on Jan. 8, 2021. Pfizer-BioNTech and Moderna COVID-19 vaccines are mRNA vaccines. World Health Organization Coronavirus disease situation dashboard presents official daily counts of COVID-19 cases and deaths worldwide, along with vaccination rates and other vaccination data, while providing a hub to other resources. In May 2022, Arcturus reported that ARCT-154 performed well as a booster for people vaccinated with Comirnaty and later reported that it raised antibodies against the Omicron variant and its subvariants.On February 28, 2022, Arcturus announced it had applied for emergency use authorization in Vietnam for ARCT-154. Cuban health authorities approved a trial for Mambisa as a booster dose on Nov. 20. The Vaccine and Infectious Disease Organization at the University of Saskatchewan has developed two vaccine candidates which use pieces of viral proteins to develop immunity against the coronavirus. Early use in: Russia. Johns Hopkins experts in global public health, infectious disease, and emergency preparedness have been at the forefront of the international response to COVID-19. As of April 2022, the company said that it had delivered over 2.8 billion doses around the world. Still, on Sept. 15, VIDO director Volker Gerdts told Global News Morning that it was moving to a Phase 2 trial after getting promising preliminary results. Updated June 13, 2022, PHASE 1 Dose: 2 doses, 3 weeks apart In early 2020, Sanofi developed a Covid-19 vaccine based on viral proteins they produced with engineered viruses that grow inside insect cells. The company said in March 2022 that it planned to make 100 million doses this year.In July 2022, Medigen released a report on its Phase 3 trial in Paraguay. authorized Johnson & Johnson boosters.SIDE EFFECTSOn April 13, 2021, the U.S. government recommended a pause in using the vaccine while it investigated reports of rare blood clots. The name is from a poem by the nineteenth-century poet Jos Marti. Dose: 2 doses, 2 weeks apart Efficacy: 82% Approved for use in: Canada, South Korea. They began Phase 1/2 trials on June 15, partnering with Morningside Ventures to manufacture and distribute the vaccine through a new company called VacEquity Global Health. Coronavirus (COVID-19) Vaccinations - Our World in Data With 18,385 more discharges, the cumulative recoveries reached 1,01,11,294.As many as 167 deaths were reported in the last 24 hours, taking the death toll to 1,51,327. Meanwhile, CureVac prepared for mass production of the vaccine. Kent Woods, former chief executive of the U.K. Using WONDER, the CDC's VAERS database search tool, Newsweek gathered adverse report data specifically on deaths following a COVID vaccine from Moderna or Pfizer. The world's lowest-income countries are far behind the rest of the world on Covid vaccination Doses administered per 100 residents - The world's poorest countries have barely started Covid. Just over a year later in January 2022, it granted full approval for the vaccine. In November 2021, Indonesia authorized the Kangtai vaccine, and the company said it was shipping 4 million doses there despite the lack of public Phase 3 trial results. Updated Aug. 31, 2022, PHASE 3 The company is betting it can offer long-lasting immunity.In October 2020, Entos launched a Phase 1 trial in Canada for their vaccine, called Covigenix VAX-001. They said that they resumed the trial with an updated version of the vaccine on July 16, 2021, and completed the trial that August.The researchers announced in November that they are evaluating an MVA-based vaccine in Phase 1 trials as a booster and in unvaccinated individuals. Others only encode the spike protein on the surface of the coronavirus. In November, they announced that the vaccine was well tolerated and produced antibodies, and released a report on the trial.In March 2021, researchers launched a Phase 2 trial of the vaccine, which delivered encouraging results in July. No pre-departure/on arrival testing The money helped AstraZeneca and Oxford embark on large late-stage trials in the United States, United Kingdom, South Africa, and elsewhere. Updated Feb. 7, 2022, PHASE 1 Recognizing the urgency of turning vaccine doses into vaccinated, protected communities, WHO, UNICEF and Gavi, the Vaccine Alliance launched the COVID-19 Vaccine Delivery Partnership (CoVDP). On Dec. 22, Novavax announced that its vaccine also lost some of its potency against the Omicron variant, but a booster shot restored much of its protection. Finally, on Nov. 9, Pfizer and BioNTech released their preliminary analysis of the first 94 cases of Covid-19 in their volunteers.Over the next month, Pfizer and BioNTech released more data on more cases. Updated June 29, 2022, PHASE 2 PHASE 3 COMBINED PHASES Of those deaths, 495 occurred following a Moderna shot, and 475 occurred following a Pfizer shot. In July, Medigen started another Phase 2 trial on children between 12 and 18 years old. But another study from outside scientists suggested that the vaccine only weakly protects against Delta. On Sept. 12, Pfizer and BioNTech announced that they would seek to expand the trial to 44,000 participants.Through the summer and into the fall, the world closely followed the Pfizer-BioNTech trial. It said on Dec. 20 that Phase 2 trials of the booster are ongoing, and serious adverse effects have not been reported. Mediterranean They say that such a strategy can help prevent reinfection and limit the spread of new variants. Vaccinename: Vidprevtyn Coronavirus News Highlights: Second dry run to take - Moneycontrol That assumption turned out to be wrong. It was the first clinical trial of a coronavirus vaccine developed in Turkey. Bahrain followed with a similar announcement on June 3. VBI announced on Sept. 29 that it had dosed the first participants in another Phase 1 trial for a vaccine meant to protect against emerging variants. In September 2020, the Chula Vaccine Research Center registered a Phase 1 trial to test it in humans. Another study from Sri Lanka, released in July, found that BBIBP-CorV produced antibody responses to the Delta variant that were as strong as those produced by natural infection. Stopped use in: Malaysia. APPROVED IN RUSSIA Dose: 2 doses, 3 weeks apart Entos instead chose the gene for a protein called nucleocapsid that sits inside the viruss membrane. Oral vaccines have been approved for diseases including polio, cholera, and typhoid fever. ACM-001 can be delivered as an intranasal spray. Results from that study suggest that the combination yielded at least a four-fold increase in antibodies in 85 percent of participants. Appointments for the shot opened on Dec. 30, and Turkey began giving Turkovac as a booster in January 2022.When Turkovac rolled out, Turkish medical associations requested that the government make the results of the Phase 3 trial public. Their booster trial is currently in Phase 2.The World Health Organization selected Inovios vaccine as one its first candidates in the Solidarity Trial Vaccine study. Updated Aug. 26, 2022, PHASE 3 The company said it was going to launch a trial on 4,500 volunteers to compare the performance of their booster to one that has already been approved. COVID-19 Vaccines | FDA - U.S. Food and Drug Administration In that group, the researchers also found the vaccine provided 100 percent protection against hospitalization and death. EARLY USE IN RUSSIA Because most coronavirus vaccines require two doses, many countries also report the number of people who have received just one dose and the number who have been fully vaccinated. On Aug. 5, another Phase 1/2 trial began, comparing ZR-202-CoV and a booster vaccine called ZR-202a-CoV to Comirnaty. On June 8, 2022, they announced that an Omicron-specific booster produced a strong increase in antibodies against the variant. In October, authorities in the eastern Chinese city of Jiaxing announced they were giving CoronaVac to people in relatively high-risk jobs, including medical workers, port inspectors and public service personnel.Indonesia gave the vaccine emergency authorization on Jan. 11, and two days later the president of Indonesia received an injection of CoronaVac on live television. New cases and deaths in the last 7 days vs. the preceding week. Storage: Stable in refrigerator for up to two years The researchers engineered NDV to carry the gene for a modified version of the coronavirus spike protein called HexaPro, developed at the University of Texas. To make the vaccine, researchers started off with another virus, called respiratory syncytial virus (RSV for short). A Phase 2 trial also provided encouraging results, followed by the launch of a 24,000-person Phase 3 trial on March 16, 2021. BOOSTERSIn June, Oxford researchers reported that a third booster of the AstraZeneca vaccine generated strong immune responses in volunteers. Oravax Medical has also applied to Israel to run another trial there. Promising preliminary results from the trial have pushed the company to accelerate the process for emergency use authorization in Vietnam. Updated April 3, 2022, PHASE 1 COVAX is co-led by the Coalition for Epidemic Preparedness Innovations (CEPI), Gavi and WHO, with UNICEF as a key delivery partner and PAHO as the procurement agent in the Americas. In January 2020, they began developing a vaccine for the coronavirus.The United States government bankrolled Modernas efforts, providing nearly $1 billion in support. VACCINE DEVELOPMENTIn early 2020, Sinovac developed the Coronavac vaccine based on inactivated coronaviruses. South Africa dropped plans to use AstraZenecas vaccine for their health care workers after a small trial failed to show it was effective against the Beta variant that had grown dominant across the country. As a result, they were able to calculate the efficacy of Covaxin against Delta by looking at the relative risk volunteers had of contracting the variant. In May 2022, the F.D.A. It lifts the efficacy of the vaccine to 92.4 percent, and 100 percent against severe Covid-19. In May 2022, Chula researchers issued a report showing that the Phase 1 volunteers produced higher antibodies than people who received Comirnaty.In an interview with the Bangkok Post, the leader of the project said that up to 30 million doses might be produced for Thailand and six other Asian countries if the vaccine proved to be safe and effective. TASS reported in June that the vaccine may go into Phase 3 trials in late summer 2022. Emergency use validation from the World Health Organization. The vaccine is an improved version of CureVacs initial Covid vaccine, CVnCoV, which delivered disappointing results in clinical trials in 2021 .After abandoning the CVnCoV trial, CureVac retooled the vaccine to create CV2nCoV. Researchers at Spanish animal health company HIPRA have created a recombinant protein vaccine against the coronavirus in humans. The company then ran a trial on healthy volunteers and found that a booster of the original strain raised their production of antibodies against all major variants.On Oct. 20, the F.D.A. The initial data from a Phase 1 trial, announced Oct. 28, indicate that the vaccine can also produce high levels of antibodies against the coronavirus in peoples noses. On Sept. 22, an NYU study suggested that Pfizer and Moderna vaccine doses which were administered to pregnant women later brought about a high amount of antibodies in their newborns. The researchers moved on to a Phase 2 trial in September 2021, giving the vaccine to immunocompromised volunteers.On Nov. 9, 2021, GeoVax announced that it has been granted exclusive rights to develop COH04S1, and market it worldwide. Updated July 20, 2021, PHASE 1 PHASE 2 COMBINED PHASES A study published in May demonstrated that Comirnaty was somewhat less effective against some variants, but still provided strong protection. Venezuela began using the vaccine in late June.On June 21, 2021, Cuban officials reported that Abdala had an efficacy of 92.28 percent. The following month, a Phase 3 trial began. For more details, see How the Sinopharm Vaccine Works. 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