Canada residents can call a provincial poison control center. Share cases and questions with Physicians on Medscape consult. Minor (1)probenecid increases effects of lisinopril by unspecified interaction mechanism. pharmacodynamic antagonism. Use Caution/Monitor. Use Caution/Monitor. It is conventionally rounded to 50mg per drop. Do not take this medicine if you know you are allergic to iodine (see SIDE EFFECTS). Monitor Closely (1)dalteparin increases toxicity of lisinopril by Other (see comment). Monitor Closely (2)voclosporin and lisinopril both increase serum potassium. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. Young children have the highest risk. Mechanism: pharmacodynamic synergism. NSAIDs decrease prostaglandin synthesis. Properly discard this product when it is expired or no longer needed. Use Caution/Monitor. Monitor BP. Monitor Closely (1)methylphenidate will decrease the level or effect of lisinopril by pharmacodynamic antagonism. Either increases toxicity of the other by Other (see comment). This concentration of iodide allows the calculation of the iodide dose per drop, if one knows the number of drops per milliliter. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals. Avoid or Use Alternate Drug. Coadministration may result in a significant decrease in renal function. Use Caution/Monitor. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. directed above, but call a doctor if you need to take KI for more than a few lisinopril, sirolimus. Dose uniformity was determined by mixing one teaspoon of KI stock solution (65 mg/5 mL) with one teaspoon of water. thyroid disease with heart disease, because these conditions may increase the Additive hypotensive effects. Washington DC: American Pharmacists Association; 2004. Avoid or Use Alternate Drug. fluphenazine increases effects of lisinopril by unspecified interaction mechanism. Mechanism: pharmacodynamic synergism. Other (see comment). Monitor Closely (1)lisinopril increases levels of digoxin by unspecified interaction mechanism. tablets (140 tablets) in a Clear Plastic Bag. These compounds contain iodine, but not in the iodide form. Each tablet contains 130mg of potassium iodide. Modify Therapy/Monitor Closely. Since it is hard to cut many pills, the State Health Commissioner says that, in an emergency, it is safe for children at school or day care centers to take the whole pill. lisinopril increases levels of potassium chloride by decreasing elimination. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.Serious - Use Alternative (1)oxaprozin, lisinopril. following table: Note: This is the amount to give your child for one single HOW SUPPLIED IOSAT (Potassium Iodide Tablets, USP 130 mg) Each white, round tablet, cross-scored on one side and the IOSAT name on the other, contains 130 mg potassium iodide. Risk of hyperkalemia. pharmacodynamic antagonism. Minor (1)thioridazine increases effects of lisinopril by unspecified interaction mechanism. In case This work was completed through a FDA contract with the Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee, Memphis, TN 38163, Arthur B. Straughn (Principal Investigator). Pharmacodynamics. lisinopril, azathioprine. Monitor blood pressure and adjust dose of antihypertensive agent as needed. [4], Potassium-iodide is a nutritional-supplement in animal feeds and also in the human diet. Coadministration may result in a significant decrease in renal function. Monitor Closely (1)lisinopril, everolimus. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. Discontinue as soon as possible when pregnancy is detected; affects renin-angiotensin system, causing oligohydramnios, which may result in fetal injury and/or death, Hypersensitivity to lisinopril/other ACE inhibitors, History of ACE inhibitor-induced angioedema, hereditary or idiopathic angioedema, Coadministration of neprilysin inhibitors (eg, sacubitril), Coadministration with aliskiren in patients with diabetes mellitus or with renal impairment (ie, GFR <60 mL/min/1.73m, Anaphylactoid reactions reported in some patients dialyzed with high-flux membranes, Hematologic effects including agranulocytosis and neutropenia/agranulocytosis reported especially in patients with renal impairment and collagen vascular disease; monitor CBC periodically with differential, Excessive hypotension with concomitant diuretics, hypovolemia, hyponatremia may occur, Neprilysin inhibitors (eg, sacubitril) with ACE inhibitors may increase angioedema risk; do not administer ACE inhibitors within 36 hr of switching to or from sacubitril/valsartan, Risk of hyperkalemia, especially in patients with renal impairment or DM or in patients taking concomitant K+-elevating drugs, ACE inhibition also causes an increase in bradykinin levels, which putatively mediates angioedema; in comparison with other patients, a higher incidence of angioedema caused by ACE inhibitors has been observed in black patients, A dry hacking cough may occur within a few months of initiating drug therapy with ACE inhibitors; exclude other causes of cough before discontinuing therapy, Cholestatic jaundice associated with ACE inhibitors; discontinue if marked elevation of hepatic transaminases or jaundice occurs, Coadministration with mTOR inhibitors (eg, temsirolimus, everolimus) may increased risk for angioedema, Discontinue STAT if patient becomes pregnant, Use caution in patients with renal impairment; renal deterioration reported in patients with low renal blood flow, Use caution in patients with severe aortic stenosis, cardiovascular disease, collagen vascular disease, hypertrophic cardiomyopathy, Dual blockade of the renin-angiotensin-aldosterone system (ie, ARB plus an ACE inhibitor) in patients with established atherosclerotic disease or heart failure or with diabetes with end organ damage is associated with a higher frequency of hypotension, syncope, hyperkalemia, and changes in renal function (including acute renal failure), as compared with use of a single renin-angiotensin-aldosterone system agent; limit dual blockade to individually defined cases, with close monitoring of renal function, Neonates with history of in utero exposure: If oliguria or hypotension occurs, support of blood pressure and renal perfusion; exchange transfusions or dialysis may be required, Angioedema of the face, extremities, lips, tongue, glottis and/or larynx, including some fatal reactions, at any time during treatment; patients with involvement of the tongue, glottis or larynx are likely to experience airway obstruction, especially patients with history of airway surgery; promptly discontinue and provide appropriate therapy and monitoring until complete and sustained resolution of signs and symptoms of angioedema has occurred, Intestinal angioedema reported; patients presented with abdominal pain (with or without nausea or vomiting); in some cases there was no prior history of facial angioedema and C-1 esterase levels were normal; symptoms resolved after stopping the ACE inhibitor, Hypotension may occur sometimes complicated by oliguria, progressive azotemia, acute renal failure or death; patients at risk of excessive hypotension include heart failure with systolic blood pressure below 100 mmHg, ischemic heart disease, cerebrovascular disease, hyponatremia, high dose diuretic therapy, renal dialysis, or severe volume and/or salt depletion of any etiology; in such patients initiate therapy under medical supervision and follow such patients for the first two weeks of treatment and whenever dose of lisinopril and/or diuretic is increased; avoid use in patients who are hemodynamically unstable after acute MI; symptomatic hypotension also possible in patients with severe aortic stenosis or hypertrophic cardiomyopathy, Patients undergoing major surgery or during anesthesia with agents that produce hypotension, lisinopril may block angiotensin II formation secondary to compensatory renin release; if hypotension occurs and considered to be due to this mechanism, it can be corrected by volume expansion, Monitor renal function periodically; changes in renal function including acute renal failure can be caused by drugs that inhibit renin-angiotensin system; patients whose renal function may depend in part on activity of the renin-angiotensin system (eg, patients with renal artery stenosis, chronic kidney disease, severe congestive heart failure, post-myocardial infarction or volume depletion) may be at particular risk of developing acute renal failure; consider withholding or discontinuing therapy in patients who develop a clinically significant decrease in renal function, Therapy can cause fetal harm when administered to a pregnant woman; use of drugs that act on renin- angiotensin system during second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death, Most epidemiologic studies examining fetal abnormalities after exposure to antihypertensive use in first trimester have not distinguished drugs affecting renin- angiotensin system from other antihypertensive agents; when pregnancy is detected, discontinue therapy as soon as possible, No data are available regarding presence of lisinopril in human milk or effects on the breastfed infant or on milk production, The drug is present in rat milk; because many drugs are secreted in human milk, and because of thepotential for serious adverse reactions in breastfed infants from ACE inhibitors, discontinue breastfeeding or discontinue therapy. When amifostine is used at chemotherapeutic doses, withhold blood pressure lowering medications for 24 hr prior to amifostine; if blood pressure lowering medication cannot be withheld, do not administer amifostine. Full one-year, no-hassle returns, money-back guarantee. Minor/Significance Unknown. Use Caution/Monitor. Two analysts each repeated the procedure five times. lisinopril increases effects of tolbutamide by pharmacodynamic synergism. Avoid coadministration with other drugs that decrease pulse or blood pressure to mitigate risk of excessive bradycardia and hypotension. Minor/Significance Unknown. This drug is available at a higher level co-pay. Comment: Low molecular weight heparins may suppress adrenal aldosterone secretion, which can potentially cause hyperkalemia. Either increases toxicity of the other by Other (see comment). Avoid or Use Alternate Drug. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. 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